{"id":147,"date":"2019-02-01T09:00:13","date_gmt":"2019-02-01T09:00:13","guid":{"rendered":"https:\/\/journals.myesr.org\/eur-radiol-exp\/2019\/02\/01\/feasibility-7-t-fluorine-magnetic-resonance-spectroscopic-imaging-19f-mrsi-tas-102-metabolite-detection-liver-patients-metastatic-colorectal-cancer\/"},"modified":"2025-10-22T13:03:26","modified_gmt":"2025-10-22T12:03:26","slug":"feasibility-7-t-fluorine-magnetic-resonance-spectroscopic-imaging-19f-mrsi-tas-102-metabolite-detection-liver-patients-metastatic-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/journals.myesr.org\/eur-radiol-exp\/blog\/feasibility-7-t-fluorine-magnetic-resonance-spectroscopic-imaging-19f-mrsi-tas-102-metabolite-detection-liver-patients-metastatic-colorectal-cancer\/","title":{"rendered":"Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cancer"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-850 alignleft\" src=\"https:\/\/journals.myesr.org\/eur-radiol-exp\/wp-content\/uploads\/sites\/4\/2025\/10\/Fig-2b-Kurk-et-al-Jan-2019.jpg\" alt=\"Fig 2b Kurk et al Jan 2019\" width=\"348\" height=\"363\" \/>This pioneering study aimed to investigate the potential of 7-T 19F-MRS to detect TAS-102 metabolites in humans. The authors set out to prove that TAS-102 cannot be detected in liver metastases of metastatic colorectal cancer patients on a normal treatment schedule, thus showing that 19F-MRS TAS-102 metabolite detection is not yet useful in clinical prediction of treatment response. 19F-MRS, however, can detect TAS-102 in phantom and murine models, which is why the use of 19F-MRS remains a potential tool to noninvasively detect and monitor the metabolism when higher dosages of TAS-102 are administered.<\/p>\n<p><strong>Article<\/strong>:<a href=\"https:\/\/eurradiolexp.springeropen.com\/articles\/10.1186\/s41747-018-0043-8\" target=\"_blank\"> Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cance<\/a>r<\/p>\n<p><strong>Authors<\/strong>: Sophie A. Kurk, Bart R. Steensma, Anne M. May, Miriam Koopman, Hans M. Hoogduin, Tijl A. van der Velden, Dennis W. J. Klomp and Wybe J. M. van der Kemp<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This pioneering study aimed to investigate the potential of 7-T 19F-MRS to detect TAS-102 metabolites in humans. The authors set out to prove that TAS-102 cannot be detected in liver metastases of metastatic colorectal cancer patients on a normal treatment schedule, thus showing that 19F-MRS TAS-102 metabolite detection is not yet useful in clinical prediction [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":27,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-147","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cancer - European Radiology Experimental<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/journals.myesr.org\/eur-radiol-exp\/blog\/feasibility-7-t-fluorine-magnetic-resonance-spectroscopic-imaging-19f-mrsi-tas-102-metabolite-detection-liver-patients-metastatic-colorectal-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cancer - European Radiology Experimental\" \/>\n<meta property=\"og:description\" content=\"This pioneering study aimed to investigate the potential of 7-T 19F-MRS to detect TAS-102 metabolites in humans. The authors set out to prove that TAS-102 cannot be detected in liver metastases of metastatic colorectal cancer patients on a normal treatment schedule, thus showing that 19F-MRS TAS-102 metabolite detection is not yet useful in clinical prediction [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/journals.myesr.org\/eur-radiol-exp\/blog\/feasibility-7-t-fluorine-magnetic-resonance-spectroscopic-imaging-19f-mrsi-tas-102-metabolite-detection-liver-patients-metastatic-colorectal-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"European Radiology Experimental\" \/>\n<meta property=\"article:published_time\" content=\"2019-02-01T09:00:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-22T12:03:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/journals.myesr.org\/eur-radiol-exp\/wp-content\/uploads\/sites\/4\/2025\/10\/header-bg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2048\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"devsk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"devsk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/journals.myesr.org\/eur-radiol-exp\/blog\/feasibility-7-t-fluorine-magnetic-resonance-spectroscopic-imaging-19f-mrsi-tas-102-metabolite-detection-liver-patients-metastatic-colorectal-cancer\/\",\"url\":\"https:\/\/journals.myesr.org\/eur-radiol-exp\/blog\/feasibility-7-t-fluorine-magnetic-resonance-spectroscopic-imaging-19f-mrsi-tas-102-metabolite-detection-liver-patients-metastatic-colorectal-cancer\/\",\"name\":\"Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cancer - 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